Tirzepatide, once weekly · Eli Lilly

The Mounjaro shot, from the label

The once-weekly tirzepatide injection for type 2 diabetes, in a pen, a vial or a KwikPen. Everything on this page comes from the prescribing information, revised 8/2026.

The Oolite team, from the FDA labels. Sources checked Sep 28, 2026.

How to take it

Once a week, at any hour, with or without a meal. In the abdomen or the thigh, or the back of the upper arm when someone else gives it, a different spot each time.

From the label

Administer MOUNJARO once weekly, any time of day, with or without meals. Inject MOUNJARO subcutaneously in the abdomen, thigh, or have another person inject MOUNJARO in the back of the upper arm. Rotate injection sites with each dose.

Mounjaro prescribing information, §2.2, revised 8/2026

The dose steps

2.5 mg to start. If more blood sugar control is needed, the dose rises by 2.5 mg, each after at least four weeks, up to 15 mg in adults.

From the label

The recommended starting dosage of MOUNJARO is 2.5 mg injected subcutaneously once weekly. … If additional glycemic control is needed, increase the dosage in 2.5 mg increments after at least 4 weeks on the current dose.

Mounjaro prescribing information, §2.1, revised 8/2026

If a dose is missed

Four days to catch up, the same window as Zepbound, the other tirzepatide.

From the label

If a dose is missed, instruct patients to administer MOUNJARO as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day.

Mounjaro prescribing information, §2.1, revised 8/2026

How long it stays in the body

From the label

The apparent population mean clearance of tirzepatide is 0.061 L/h with an elimination half-life of approximately 5 days, enabling once-weekly dosing.

Mounjaro prescribing information, §12.3, revised 8/2026

Sources

This page is information, not medical advice. Read the medical disclaimer.

Questions about the Mounjaro®

All answers

Oolite

The GLP-1 tracker for the pill and the shot.

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