Semaglutide, once weekly · Novo Nordisk

The Ozempic shot, from the label

The once-weekly semaglutide injection for type 2 diabetes, in a pen that holds several weekly doses. Everything on this page comes from the prescribing information, revised 05/2026.

The Oolite team, from the FDA labels. Sources checked Sep 28, 2026.

How to take it

Once a week, on the same day, at any hour, with or without a meal. In the abdomen, the thigh or the upper arm, a different spot each week within the same area.

From the label

Administer OZEMPIC once weekly, on the same day each week, at any time of the day, with or without meals. Inject OZEMPIC subcutaneously in the abdomen, thigh, or upper arm. Instruct patients to use a different injection site each week when injecting in the same body region.

Ozempic prescribing information, §2.1, revised 05/2026

The dose steps

0.25 mg for four weeks, then 0.5 mg. From there the prescriber may go to 1 mg and then 2 mg, each after at least four weeks, based on blood sugar control.

From the label

Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks. … After 4 weeks on the 0.25 mg dosage, increase the dosage to 0.5 mg once weekly. … The maximum recommended dosage is 2 mg once weekly.

Ozempic prescribing information, §2.2, revised 05/2026

If a dose is missed

From the label

If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once-weekly dosing schedule.

Ozempic prescribing information, §2.1, revised 05/2026

How long it stays in the body

From the label

With an elimination half-life of approximately 1 week, semaglutide will be present in the circulation for about 5 weeks after the last dose.

Ozempic prescribing information, §12.3, revised 05/2026

Sources

This page is information, not medical advice. Read the medical disclaimer.

Questions about the Ozempic®

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