The Zepbound shot, from the label

How to take it

Once a week, at any hour, with or without a meal. In the abdomen or the thigh, or the back of the upper arm when someone else gives it, a different spot each time.

From the label

Administer ZEPBOUND once weekly at any time of day, with or without meals. Inject ZEPBOUND subcutaneously in the abdomen, thigh, or another person should inject in the back of the upper arm. Rotate injection sites with each dose.

Zepbound prescribing information, §2.4, revised 8/2026

The dose steps

2.5 mg for four weeks to start, then 5 mg. From there the dose may rise by 2.5 mg, each after at least four weeks, up to 15 mg.

From the label

The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks. The 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage.

Zepbound prescribing information, §2.1, revised 8/2026

If a dose is missed

Four days to catch up, where Wegovy and Ozempic give other windows: each label has its own.

From the label

If a dose is missed, instruct patients to administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day.

Zepbound prescribing information, §2.3, revised 8/2026

How long it stays in the body

From the label

The elimination half-life is approximately 5-6 days in patients with overweight or obesity, and in patients with OSA and obesity.

Zepbound prescribing information, §12.3, revised 8/2026