Side effectsOct 31, 2026
Does Wegovy increase your heart rate?
One to four beats at rest on average, a bigger jump in one person in four. What the label measured on the weekly shot, and what it asks you to report.
Semaglutide, once weekly · Novo Nordisk
The Wegovy shot, from the label
The once-weekly semaglutide injection, the same molecule as the Wegovy pill. Everything on this page comes from the prescribing information, revised 06/2026, which covers the shot and the tablets together.
The Oolite team, from the FDA labels. Sources checked Sep 28, 2026.
How to take it
Once a week, on the same day, at any hour, with or without a meal. In the abdomen, the thigh or the upper arm, a different spot each time.
From the labelAdminister WEGOVY injection once weekly, on the same day each week, at any time of day, with or without meals. Inject WEGOVY subcutaneously in the abdomen, thigh, or upper arm. The time of day and the injection site can be changed without the need for a dosage modification. Rotate injection sites with each dose.
The dose steps
Four weeks on each step: 0.25 mg, then 0.5 mg, 1 mg and 1.7 mg, then the maintenance dose from week 17, set by the indication (for adults, 1.7 or 2.4 mg, and for weight reduction up to 7.2 mg after at least four weeks on 2.4 mg). The label allows a step to be held longer when it is not tolerated.
From the labelThe recommended starting dosage of WEGOVY injection is 0.25 mg administered subcutaneously once weekly. … If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.
If a dose is missed
The rule turns on the next scheduled shot: more than two days away, take the missed one as soon as possible; less than two days away, skip it and keep the usual day. Two or more missed in a row means restarting lower, with the prescriber.
From the labelIf 2 or more consecutive doses of WEGOVY injection are missed, reinitiate dosage escalation at a lower dosage to reduce the risk of gastrointestinal adverse reactions.
How long it stays in the body
Semaglutide has an elimination half-life of about one week, the same for the shot and the pill.
From the labelWith an elimination half-life of approximately 1 week, semaglutide will be present in the circulation for about 5 to 7 weeks after the last injectable dose of 2.4 mg or 7.2 mg or oral dose of 25 mg.
Sources
This page is information, not medical advice. Read the medical disclaimer.
Questions about the Wegovy® injection
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Oolite
The GLP-1 tracker for the pill and the shot.
The 30 minute timer, your shot day, the level chart and the dose reminder, on iPhone, with Apple Watch to log. Free to download, then a 14-day free trial.